BCL-2 protein family

BCL-2 protein family by Claudio Hetz Download PDF EPUB FB2

In this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCL‑2 family of proteins in apoptosis, physiology and disease.

An important focus Author: Claudio Hetz. In this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCL‑2 family of proteins in apoptosis, physiology and disease.

An important focus. His lab uses animal models to investigate the signaling responses involved in protein misfolding disorders and the role of the BCL‑2 protein family in stress conditions.

He was recently awarded with the TWAS‑ROLAC Young Scientist BCL-2 protein family book Format: Paperback. The chapters in this book cover topics such as the relevance of BCL-2 proteins in health and disease; evaluating cellular dependencies to specific BCL-2 family proteins; flow-cytometry-based methods for measuring BCL-2 proteins and mitochondrial-based cell death; measuring activity and interactions of BCL-2 family proteins.

BCL-2 family proteins, which have either pro- or anti-apoptotic activities, have been studied intensively for the past decade owing to their importance in the regulation of apoptosis, tumorigenesis and Cited by: In this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCL‑2 family of proteins in apoptosis, physiology and disease.

An important focus of this volume is considering the potential TH ERA PEUT IC benefits of targeting apoptosis pathways in the context of human disease Price: $ The chapters in this book cover topics such as the relevance of BCL-2 proteins in health and disease; evaluating cellular dependencies to specific BCL-2 family proteins; flow-cytometry-based methods for measuring BCL-2 proteins and mitochondrial-based cell death; measuring activity and interactions of BCL-2 family proteins in the presence of.

This book highlights the relevance of the BCL-2 family of proteins in apoptosis, physiology and disease. It examines the potential therapeutic benefits of targeting apoptosis pathways in the context Read more. The BCL-2 family is composed of anti- and pro-apoptotic proteins that function to regulate the intrinsic pathway of apoptosis.

1,2 Anti-apoptotic members: BCL-2, BCL-X L, BFL-1/A1, BCL-W and MCL-1 3; Pro-apoptotic members: BAX, BAK, BIM, BID, BOK, BAD, PUMA and NOXA 3,4; When working in concert, these proteins regulate apoptosis to maintain normal cellular homeostasis.

1,5. The BCL-2 family of proteins and its role in apoptosis. The BCL-2 family of proteins is known as an important gatekeeper to the apoptotic response. This group of structurally related proteins comprises pro-apoptotic and anti-apoptotic members (Figure ) that interact with one another. The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible release of intermembrane space proteins, subsequent caspase activation and apoptosis.

Bcl-2 family proteins serve as critical regulators of pathways involved in apoptosis, acting to either inhibit or promote cell death. Altered expression of these proteins occurs commonly in human.

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell suicide programme that is essential for development, tissue homeostasis and immunity. The Bcl-2 proteins form a family of evolutionarily related proteins which are essential for maintaining the balance between cell death and cell proliferation, with different family members acting as either positive or negative modulators of apoptosis.

BCL-2 protein family: essential regulators of cell death. [Claudio Hetz;] Home. WorldCat Home About WorldCat Help. Search. Search for Library Items Search for Lists Search for Contacts Search for a Library.

Create lists, bibliographies and reviews: or Search WorldCat. Find items in libraries near you. It is believed that the Bcl-2 family protein Bok has a redundant role similar to Bax and Bak in regulating apoptosis. We report that this protein interacts with the key enzyme involved in uridine biosynthesis, uridine monophosphate synthetase, and positively regulates uridine biosynthesis and chemoconversion of 5-fluorouracil (5-FU).

Bok-deficient cell lines are resistant to 5-FU. Bclrelated protein A1 is a protein that in humans is encoded by the Function. This gene encodes a member of the bcl2 protein family.

The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide BCL2-related protein A1 has been shown to interact with: Bcl Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.

Bcl-2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving.